Organs-on-chips provide several advantages over traditional in vitro and in vivo methods: 1. Human-Relevant Data: They use human cells, which makes the data more relevant to human physiology compared to animal models. 2. Reduced Animal Testing: They contribute to the 3Rs principle (Replacement, Reduction, and Refinement) by minimizing the need for animal testing. 3. Complex Interactions: They can replicate complex tissue interfaces and dynamic flows, which are difficult to achieve in conventional cell cultures. 4. High-Throughput Screening: They can be integrated into automated systems for high-throughput screening of multiple compounds simultaneously.
