Alternatives to G-CSF include other hematopoietic growth factors such as granulocyte-macrophage colony-stimulating factor (GM-CSF) and erythropoietin, which target different lineages of blood cells. Additionally, new therapies and small molecules that mimic or enhance the effects of G-CSF are being developed. These alternatives may offer distinct safety profiles and mechanisms of action, providing options for patients who experience adverse effects from G-CSF.