What are the Applications of PAS Staining in Toxicology?
PAS staining is used in several applications within toxicology, including:
Hepatotoxicity Studies: PAS staining is used to assess liver damage by detecting glycogen depletion or accumulation, which may be indicative of impaired liver function. Nephrotoxicity Assessment: The technique helps in evaluating kidney damage by highlighting changes in the basement membrane and glomerular alterations due to toxic exposure. Carcinogenicity Testing: PAS staining can reveal abnormal cell growth and differentiation, aiding in the identification of potential carcinogenic effects of chemicals. Endocrine Disruption: By visualizing changes in tissue architecture, researchers can infer the impact of endocrine disruptors on hormone-regulated tissues.
