What are the Applications of PBPK Models in Toxicology?
PBPK models have a wide range of applications in toxicology, including: - Risk Assessment: Estimating the safety margins for exposure to toxic substances. - Drug Development: Predicting human pharmacokinetics from preclinical data. - Regulatory Submissions: Providing mechanistic insights supporting regulatory decisions. - Chemical Safety: Evaluating the potential toxic effects of new chemicals before they are marketed.
