What Are the Challenges in Studying Polymorphisms?
While the potential for using polymorphisms in toxicology is vast, several challenges exist. One major challenge is the complexity of gene-environment interactions. The effect of a polymorphism may vary depending on environmental exposures, lifestyle factors, and other genetic variations. Moreover, the polygenic nature of many traits means that multiple polymorphisms may contribute to a single effect, complicating the identification of causal relationships.
