What are the Challenges in Using iPSCs for Toxicology?
Despite their advantages, iPSCs also present certain challenges. The reprogramming process can introduce genetic and epigenetic variations, which may affect the reproducibility and consistency of results. Additionally, the differentiation of iPSCs into specific cell types requires precise protocols to ensure the cells mimic the physiological properties of native cells. The scalability of iPSC-derived cells for high-throughput screening also poses logistical challenges. Furthermore, the cost and time associated with generating and maintaining iPSCs can be significant.
