read across

What are the Challenges of Read Across?


While read across offers numerous advantages, it also presents several challenges:
Uncertainty: Predicting toxicity based on analogues can introduce uncertainties, particularly when the structural similarity is not optimal.
Data availability: The approach relies heavily on the availability of high-quality data for the source chemicals.
Regulatory scrutiny: Regulatory agencies may require extensive justification and evidence to accept read across conclusions, making the process time-consuming.

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