What are the Criteria for a Successful Read Across?
For a read across to be considered robust and reliable, certain criteria must be met:
Structural similarity: The source and target chemicals must have a high degree of structural similarity. Consistent mode of action: The chemicals should exhibit the same toxicological mechanisms and biological pathways. Quality of data: The available data for the source chemicals must be of high quality and relevance. Transparent documentation: The rationale and methodology for the read across should be thoroughly documented and transparent.
