What are the Clinical Implications of Genetic Polymorphisms in Toxicology?
The presence of certain genetic polymorphisms can have significant clinical implications. For instance, individuals with specific polymorphisms in the CYP2C9 gene may require lower doses of the anticoagulant warfarin to avoid bleeding complications. Similarly, polymorphisms in the TPMT (Thiopurine S-methyltransferase) gene can affect the metabolism of thiopurine drugs used in cancer treatment, necessitating dose adjustments to prevent toxicity.
