Which Genes are Commonly Studied in Toxicology for Polymorphisms?
Several genes are frequently studied for their polymorphisms in the context of toxicology. These include:
1. CYP450 genes, such as CYP2D6 and CYP3A4, which are involved in the metabolism of a wide range of drugs and toxins. 2. GST (Glutathione S-Transferase) genes, which play a role in the detoxification of reactive oxygen species and xenobiotics. 3. NAT (N-acetyltransferase) genes, which are involved in the metabolism of certain drugs and carcinogens. 4. UGT (UDP-glucuronosyltransferase) genes, which are important for the conjugation and elimination of various endogenous and exogenous compounds.
