How do Genetic Polymorphisms Affect Drug Metabolism?
Genetic polymorphisms can significantly impact drug metabolism. For example, variations in the genes encoding for enzymes such as cytochrome P450 (CYP450) can lead to differences in how drugs are metabolized. Some individuals may metabolize drugs too quickly, reducing the drug's effectiveness, while others may metabolize drugs too slowly, increasing the risk of toxicity. Understanding these polymorphisms can help in personalizing drug therapies for better efficacy and safety.
