What are the Common Effects of Toxins on cAMP Levels?
Toxins can either increase or decrease intracellular cAMP levels, resulting in varying toxicological outcomes. For instance, pertussis toxin, secreted by Bordetella pertussis, inhibits Gi proteins, leading to elevated cAMP levels and disrupting cellular function. Conversely, some toxins reduce cAMP levels, impairing processes such as metabolism and cell proliferation. These fluctuations can lead to adverse effects, including cardiovascular toxicity, neurotoxicity, and immune dysregulation.
