Two of the most commonly used opioid antagonists are Naloxone and Naltrexone. Naloxone is frequently used in acute overdose situations due to its rapid onset of action. It can be administered intravenously, intramuscularly, or intranasally. Naltrexone, on the other hand, is used for long-term management of opioid dependence and is typically administered orally or as an extended-release injectable.
