Various animals are employed in toxicological research, each offering unique advantages. The most commonly used species include rats, mice, rabbits, guinea pigs, and non-human primates. Rodents, such as rats and mice, are popular due to their small size, ease of handling, and well-understood genetics. Rabbits are often used for ocular toxicity tests, while guinea pigs are preferred for skin sensitivity studies. Non-human primates, though used less frequently due to ethical concerns and higher costs, provide a closer approximation to human physiology for certain complex studies.
