What Are the Consequences of Citric Acid Cycle Inhibition?
Inhibition of the citric acid cycle can lead to:
- Energy Deficiency: Since the cycle is pivotal for ATP production, its inhibition can cause a severe energy crisis in cells. - Lactic Acidosis: Accumulation of pyruvate can lead to increased lactate production, causing acidosis, which can be a clinical indication of cycle disruption. - Oxidative Stress: Imbalance in the cycle can lead to increased production of reactive oxygen species, resulting in oxidative stress and potential cellular damage.
