How Can Disruption of the Citric Acid Cycle Be Detected?
Disruption of the cycle can manifest in several ways:
- Metabolomics: This emerging field can be used to detect changes in the levels of intermediates in the cycle, providing clues to potential disruptions. - Enzyme Assays: Measuring the activity of key enzymes in the cycle can help identify specific points of inhibition by toxicants. - Biomarkers: Some disruptions might lead to the accumulation of specific metabolites that can serve as biomarkers for toxic exposure.
