What Are the Effects of Circadian Disruption on Toxicity?
Disruption of the SCN can lead to a misalignment of circadian rhythms, known as circadian misalignment. This can increase susceptibility to various health issues, including metabolic disorders, cancer, and cardiovascular diseases. In toxicology, circadian disruption can modify the body's response to environmental toxins and pharmaceuticals, potentially leading to increased toxicity or reduced efficacy. For example, shift workers, who often experience circadian misalignment, may have altered responses to chemical exposures.
