The SCN orchestrates daily physiological and behavioral rhythms, which are crucial for maintaining homeostasis. In toxicology, the timing of exposure to toxic substances can significantly impact their effects. Disruption of the SCN and, consequently, the circadian rhythm could lead to varied responses to toxicants. For instance, certain toxins may cause more harm when administered at night compared to during the day, due to the body's natural fluctuations in detoxification enzyme activity.
