The SCN regulates the expression of genes involved in detoxification processes, including cytochrome P450 enzymes. These enzymes are responsible for the metabolism of numerous xenobiotics and endogenous compounds. Circadian regulation ensures that detoxification processes are optimized according to the time of day, which can affect the metabolism and clearance of toxins. Disruption of these rhythms may impair detoxification and increase the risk of toxicity.
