What are the Endogenous and Exogenous Ligands of AhR?
AhR can bind a variety of ligands. Exogenous ligands include environmental pollutants such as dioxins, PAHs, and PCBs. These compounds are often persistent organic pollutants that may cause adverse health effects. Endogenous ligands include tryptophan metabolites, such as kynurenine and indole derivatives, that play roles in normal physiological processes, including immune regulation and vascular development.
