What Are the Toxicological Implications of AhR Activation?
AhR activation is associated with numerous toxicological effects. The receptor mediates the toxic effects of several environmental contaminants, contributing to carcinogenesis, teratogenesis, and immunotoxicity. For example, exposure to polychlorinated biphenyls (PCBs) and PAHs can lead to the unwanted activation of AhR, resulting in the disruption of normal cellular functions and increased risk of cancer. Additionally, chronic activation of AhR by environmental ligands can lead to altered immune responses and developmental abnormalities.
