What Are the Implications of Cytoskeletal Disruption?
The disruption of the cytoskeleton can have numerous implications in toxicology, including:
Impaired Cell Division: When microtubules are disrupted, cells may experience aberrant division, leading to aneuploidy or cell cycle arrest. Altered Cell Shape and Motility: Changes in actin dynamics can result in altered cell morphology and impaired movement, affecting processes like wound healing and immune response. Compromised Intracellular Transport: Disruption of microtubule networks can impair the transport of organelles and vesicles within cells, leading to cellular dysfunction. Increased Susceptibility to Apoptosis: Cytoskeletal damage can trigger signaling pathways leading to apoptosis, contributing to tissue damage and disease.
