What Are the Implications of IgA Deficiency for Drug Metabolism?
IgA deficiency may influence the absorption, distribution, metabolism, and excretion (ADME) of drugs. The altered mucosal barrier can lead to increased absorption of orally administered drugs, potentially resulting in higher systemic concentrations and increased risk of adverse effects. Moreover, the immune response to drug antigens can be impaired, potentially affecting the efficacy and safety of vaccines and biologic therapies.
