What Are the Implications of Impaired Programmed Cell Death?
Impairment of programmed cell death can lead to severe consequences, including cancer, autoimmune diseases, and degenerative disorders. In toxicology, the failure to activate appropriate PCD in response to toxic insults can result in the survival of damaged cells, contributing to carcinogenesis. Conversely, excessive activation of PCD can lead to tissue injury and organ dysfunction, as seen in conditions like toxic hepatitis or neurodegeneration.
