What Are the Implications of Lipofuscin Accumulation in Diseases?
Lipofuscin accumulation is associated with various age-related diseases, including neurodegenerative disorders like Alzheimer's disease and Parkinson's disease. In these conditions, the pigment is often found in high concentrations in neurons, indicating oxidative damage and metabolic stress. Toxicological studies suggest that environmental pollutants and toxicants could contribute to the pathogenesis of such disorders through the promotion of lipofuscin accumulation.
