What are the implications of uncertainty for risk assessment?
Uncertainty in toxicology has direct implications for risk assessment. It affects the determination of safety thresholds, such as the reference dose (RfD) or acceptable daily intake (ADI). Regulators often incorporate uncertainty factors to account for these unknowns, but this can lead to either overly conservative or insufficiently protective standards. Understanding and communicating uncertainty is crucial for informed decision-making and public trust.
