What is the Role of Histone Modification in Disease Mechanisms?
Epigenetic changes, including histone modifications, play a significant role in the pathogenesis of numerous diseases. These modifications can lead to the inappropriate activation or repression of genes involved in critical cellular processes such as cell cycle regulation, apoptosis, and DNA repair. For example, aberrant histone methylation patterns have been implicated in the development of cancers, where they contribute to the silencing of tumor suppressor genes or the activation of oncogenes.
