MTHFR polymorphisms can significantly impact drug metabolism, influencing the effectiveness and toxicity of certain medications. For instance, individuals with certain MTHFR mutations may have altered metabolism of drugs that rely on methylation for activation or deactivation. This can lead to either suboptimal therapeutic effects or increased risk of adverse drug reactions. Understanding an individual's MTHFR status can help tailor drug dosages and treatment plans to improve efficacy and safety.
