The long-term effects of vindesine can vary depending on the treatment duration and individual patient factors. Persistent neuropathy and prolonged myelosuppression are potential long-term toxicities. In some cases, there may be an increased risk of developing secondary malignancies due to the DNA-damaging effects of chemotherapy. It is critical to weigh the benefits of vindesine treatment against the potential for long-term adverse effects, with decisions tailored to the patientâs overall health and cancer prognosis.