The primary toxicological concerns associated with vindesine include myelosuppression, neurotoxicity, and gastrointestinal disturbances. Myelosuppression is the most significant dose-limiting toxicity, manifesting as leukopenia, neutropenia, and anemia. Neurotoxic effects can include peripheral neuropathy, characterized by tingling, numbness, and muscle weakness. Gastrointestinal effects may involve nausea, vomiting, and constipation, which are common with many chemotherapeutic agents.
