What Are the Mechanisms of Toxicant-Induced Hematological Disorders?
The mechanisms through which toxicants induce hematological disorders vary but often involve the disruption of cellular processes. For example, benzene metabolites interfere with DNA synthesis and repair, leading to mutations and bone marrow suppression. Metals like lead inhibit key enzymes in heme production, causing anemia. Some toxicants generate reactive oxygen species (ROS), resulting in oxidative damage to blood cells and membranes.
