What are the Methods to Assess Genomic Stability in Toxicology?
Several methods are employed to evaluate genomic stability in toxicology:
Comet Assay: This technique measures DNA strand breaks in individual cells. It is a sensitive method for detecting DNA damage induced by toxicants. Micronucleus Test: This assay evaluates the formation of micronuclei, which are indicative of chromosomal instability and genotoxicity. Cytogenetic Analysis: Techniques like fluorescence in situ hybridization (FISH) are used to detect chromosomal aberrations. Gene Expression Profiling: Analyzing changes in gene expression can provide insights into the mechanisms of genomic instability.
