Disulfiram can interact with several medications, leading to potentially harmful effects. For instance, it should not be used with metronidazole, as this combination can cause a psychotic reaction similar to the disulfiram-alcohol reaction. Additionally, disulfiram can interact with anticoagulants, phenytoin, and isoniazid, altering their effects and increasing the risk of adverse reactions. Patients should be advised to inform their healthcare provider of all medications they are taking.
