While disulfiram is effective in deterring alcohol consumption, it can also have toxic effects, especially if not used properly. One of the most serious reactions is the disulfiram-alcohol reaction, which can range from mild to severe. Symptoms include intense flushing, headache, respiratory difficulty, nausea, vomiting, sweating, thirst, chest pain, palpitations, dyspnea, hyperventilation, tachycardia, hypotension, syncope, weakness, vertigo, blurred vision, and confusion.