What Are the Potential Drug Interactions with Vinblastine?
Vinblastine can interact with other medications that affect the cytochrome P450 enzyme system, potentially altering its metabolism. For instance, drugs that inhibit CYP3A4, such as certain antifungals and antibiotics, may increase vinblastine levels in the body, leading to enhanced toxicity. Conversely, drugs that induce CYP3A4 may reduce vinblastine's efficacy. Additionally, vinblastine should be used cautiously with other myelosuppressive agents to avoid compounded bone marrow suppression.
