What are the primary toxicological concerns with amikacin?
The main toxicological concerns associated with amikacin use are nephrotoxicity and ototoxicity. These adverse effects are related to the drug's mechanism of action and pharmacokinetics. Nephrotoxicity refers to kidney damage, which can manifest as an increase in serum creatinine and decrease in creatinine clearance. Ototoxicity affects the inner ear, potentially leading to hearing loss and balance disorders. The risk of these toxic effects increases with prolonged use, high doses, and in patients with pre-existing kidney problems.
