What mechanisms underlie amikacin-induced ototoxicity?
Ototoxicity from amikacin involves damage to the hair cells in the cochlea and vestibular apparatus. The drug can induce the production of reactive oxygen species, leading to oxidative stress and eventual cell death. This damage can result in sensorineural hearing loss and balance disturbances. Ototoxicity is often irreversible, making early detection and intervention critical.
