How can amikacin toxicity be monitored and prevented?
Preventive measures include adjusting the dose based on renal function and maintaining adequate hydration. Therapeutic drug monitoring, especially measuring peak and trough serum levels, helps ensure that amikacin concentrations remain within the therapeutic window. Audiometric testing can be used to monitor for early signs of ototoxicity. Close monitoring of renal function and hearing during therapy is crucial to mitigate the risk of toxicity.
