Niemann-Pick Disease is a group of inherited metabolic disorders characterized by the harmful accumulation of lipids in various organs, including the brain, liver, and spleen. This accumulation is due to the body's inability to metabolize these lipids properly. The disease is classified into different types (A, B, and C), each with distinct symptoms and genetic causes. Understanding the pathophysiology of Niemann-Pick is essential for toxicologists, as it provides insights into how genetic and biochemical factors can influence the body's response to various toxins.
