What Are the Toxicological Implications of PAH Inhibition?
Inhibition of phenylalanine hydroxylase, either through genetic mutations or external factors, can lead to toxicological consequences. Elevated phenylalanine levels disrupt normal brain function due to competitive inhibition of amino acid transport across the blood-brain barrier, leading to reduced synthesis of neurotransmitters such as dopamine and serotonin. This disruption can have profound effects on mental health and cognitive development.
