Are There Environmental or Dietary Factors Affecting PAH Function?
While PAH activity is primarily determined by genetic factors, environmental and dietary influences can modulate its function. For instance, diets high in phenylalanine, such as those containing excessive amounts of protein or artificial sweeteners like aspartame, can exacerbate the effects of PAH deficiency. Therefore, individuals with PKU must adhere to a specially formulated diet that limits phenylalanine intake to prevent toxic accumulation.
