Hyperlipidemia can be caused by a combination of genetic, lifestyle, and environmental factors. Genetic predispositions, such as familial hypercholesterolemia, play a crucial role. However, lifestyle factors such as a diet high in saturated fats, trans fats, and cholesterol, along with physical inactivity, are significant contributors. In toxicology, certain chemicals and drugs can also induce hyperlipidemia. For example, exposure to persistent organic pollutants (POPs) and certain industrial chemicals, like dioxins and polychlorinated biphenyls (PCBs), have been linked to disruptions in lipid metabolism.
