Pancytopenia can be induced by exposure to toxic chemicals and medications that suppress or damage the bone marrow. Common culprits include: - Chemotherapeutic drugs: While effective in treating cancer, these agents can also destroy rapidly dividing cells in the bone marrow. - NSAIDs: Some non-steroidal anti-inflammatory drugs have been associated with bone marrow suppression in susceptible individuals. - Heavy metals: Exposure to metals like lead, mercury, or arsenic can lead to bone marrow toxicity and pancytopenia. - Benzene: A component of industrial solvents and a byproduct of cigarette smoke, benzene is a well-known cause of bone marrow suppression. - Antibiotics: Certain antibiotics, such as chloramphenicol, are notorious for their potential to cause aplastic anemia, a severe form of pancytopenia.
