Several factors can affect the immunogenicity of a substance:
Structural Characteristics: The molecular structure, size, and presence of certain motifs in a protein can influence its immunogenicity. Formulation and Delivery: The way a substance is formulated or delivered can affect its immunogenic potential, with some delivery methods being more immunogenic than others. Patient-Specific Factors: Genetic makeup, underlying disease conditions, and concurrent medications can all impact an individual's immune response.
