Hemolytic Uremic Syndrome (HUS) is a severe condition that primarily affects the kidneys and is characterized by the triad of acute renal failure, thrombocytopenia, and microangiopathic hemolytic anemia. It is most commonly triggered by an infection with Shiga toxin-producing Escherichia coli (STEC), but it can also stem from various other toxins, medications, and underlying health conditions.