Ciguatera poisoning is one of the most common forms of fishborne poisoning worldwide, with an estimated 50,000 cases occurring each year. It is particularly prevalent in the Caribbean, Pacific Islands, and Indian Ocean regions. The economic impact includes costs related to healthcare, lost productivity, and decreased tourism in affected areas. Efforts are underway to better understand the distribution of ciguatoxins and to develop predictive models for outbreak risk, which could aid in mitigation strategies.