In toxicology, acetyl CoA is significant because it is involved in the bioactivation of xenobiotics, which are compounds foreign to the body, such as drugs and environmental chemicals. Some toxins require metabolic activation, and acetyl CoA can participate in conjugation reactions that transform these compounds into more water-soluble and excretable forms. However, certain toxins can interfere with the normal production or function of acetyl CoA, leading to metabolic disturbances and toxicity.
