What is the role of genetic factors in substantia nigra toxicity?
Genetic factors can modify an individual's susceptibility to toxins that affect the substantia nigra. Several genes involved in detoxification pathways, such as glutathione S-transferase and cytochrome P450, can influence the extent of damage in response to toxic exposure. Additionally, mutations in genes related to mitochondrial function and oxidative stress response, such as Parkin and PINK1, are associated with increased vulnerability to neuronal damage.
