How does oxidative stress influence substantia nigra degeneration?
Oxidative stress is a key mechanism in the degeneration of the substantia nigra. The dopaminergic neurons in this region are prone to oxidative damage due to the auto-oxidation of dopamine, which generates free radicals. Toxins that enhance oxidative stress can accelerate the degeneration of these neurons. Antioxidants and other therapeutic strategies aimed at reducing oxidative stress are being explored to protect the substantia nigra from toxic insults.
