Can MTHFR Status Influence Nutritional Requirements?
Yes, individuals with MTHFR polymorphisms may have different nutritional requirements, particularly concerning folate and vitamin B12. These nutrients are crucial for supporting the methylation cycle and compensating for reduced enzyme activity. Supplementation with the active form of folate, 5-methyltetrahydrofolate (5-MTHF), may be beneficial for those with MTHFR mutations to ensure adequate methylation and detoxification capacity.
